IL-2 infusion abrogates humoral immune responses in humans

MHC IIB Genetic Diversity and its Association With Humoral Immune Responses in Commercial Turkey

Background: Major histocompatibility complex (MHC) is one of the best characterized genetic regions controlling immune responses against vaccines. Identifying the association between MHC haplotypes and improved immune responses would be useful in genetic breeding strategies in animals. OBJECTIVES: MHC class II B genetic diversity and its association with humoral immune responses against Newcast...

Humoral immune responses after rabies infection.

740 Effect of Anti - Il - 2 on Immune Responses

A large body of exper imental data indicates that T cell growth factor, interleukin 2 (IL-2), j participates in a n u m b er o f in vitro assays for immune responses. For example, IL-2 has been shown to maintain the in vitro proliferat ion of antigen-specific, cytolytic, and helper T cell lines (1, 2); to contr ibute to the format ion of cytotoxic T lymphocytes in cultures stimulated with alloa...

HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.

Histone deacetylase inhibitors (HDACi) can modulate innate antiviral responses and render tumors more susceptible to oncolytic viruses (OVs); however, their effects on adaptive immunity in this context are largely unknown. Our present study reveals an unexpected property of the HDACi MS-275 that enhances viral vector-induced lymphopenia leading to selective depletion of bystander lymphocytes an...

Humoral immune responses in CD40 ligand-deficient mice

Individuals with X-linked hyper-IgM syndrome fail to express functional CD40 ligand (CD40L) and, as a consequence, are incapable of mounting protective antibody responses to opportunistic bacterial infections. To address the role of CD40L in humoral immunity, we created, through homologous recombination, mice deficient in CD40L expression. These mice exhibited no gross developmental deficiencie...